Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study
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چکیده
منابع مشابه
Rare PPARA variants and extreme response to fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study.
OBJECTIVE Fenofibrate, a peroxisome proliferator-activated receptor-α (PPARα) agonist, reduces triglyceride (TG) concentrations by 25-60%. Given significant interindividual variations in the TG response, we investigated the association of PPARA rare variants with treatment response in the Genetics of Lipid-Lowering Drugs and Diet Network study. METHODS We calculated the change in the TG conce...
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ژورنال
عنوان ژورنال: Pharmacogenetics and Genomics
سال: 2012
ISSN: 1744-6872
DOI: 10.1097/fpc.0b013e328351a486